Assessment of Genetic Variation of alfa- and beta-Thalassemia Disorder among Marriage Applicants in Abadan and Khorramshahr

Thalassemia is a hereditary anemia. Two main types are classified as α-and β -Thalassemia.More than 95 % of known cases of α- Thalassemia is due to the deletion of one or two genes, α- globin chains of chromosomes (2). Subject and In this cross-sectional study, 17,581persons, blood parameters were measured. subjects having MCV <80, MCH <27, HBA2 ≥ 3/5 of the carriers β- Thalassemia gene were considered, from whom 50 persons were andomly selected and genetic laboratory to identify the mutation was referred(4). From 17,581, 995 applicant, equivalent (5.6%) of carriers of β-thalassemia trait with frequency variation in mutatiomn gene in IVSІІ-1(25%), IVSІ-110 (16%), CD 36/37(15%), IVSІ-S(8%), CD5(9%), IVSІ-6(7%), IVSІ-1(5%), CD39(5%).While the genotype frequencies for α-thalassemia mutations were αα/med- -with 11percent and -α3.7 /-α3.7, αα/-α4.2with10% and 7% respectively Eighty of these cases were carrier of deletion mutation genotype αα/αpoly A2α and 9% α-thalassemia mutation genotype were non-deletion (4). This study showed that the prevalence of thalassemia minor in Abadan and Khorramshahr 5.6 percent is. The most common mutation was IVSII-I type. The frequency of α- thalassemia is 6.65 percent. The α-gene carriers and the most alpha chain gene disorders group αα /-α3.7with50% frequency(6).