Investigating the Effect of Zinc Chloride on Liver Hemorrhage Control; an Animal Model Study

The control of parenchymal hemorrhage especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to determine the hemostatic effect of zinc chloride on controlling the bleeding from liver parenchymal tissue. In this animal model study 60 male Wistar rats were used. A length of two cm and a depth of half a cm incision was made on each mouse’s liver and the hemostasis time was measured using zinc chloride different concentrations (5%, 10%, 15%, 25%, and 50%) and the control method (i.e. control of bleeding by suturing). In all the groups complete hemostasis occurred, the hemostasis time of zinc chloride concentration groups was significantly less than that of the control group. (P < 0.001). At concentrations of 5%, 10% and 15% zinc chloride groups and suture group, pathological grade one was seen. Also, in the 25% and 50% zinc chloride groups, pathological grade two was the most common grade (respectively 70% and 80%). Zinc chloride is an effective hemostatic agent in controlling liver parenchymal tissue hemorrhage in an animal model and at lowest concentration (5%) also could control the liver bleeding.