The effect of probiotic primalac, prebiotic fermact and antibiotic virginiamycin on reduction colonization Clostridium perfringens in necrotic enteritis challenge model of broilers

This work was conducted to study the effect of probiotic, prebiotic and antibiotic on reducing colonization of C. perfringens, associated necrotic enteritis in broilers. In this experiment, 225 day-old male chicks (Cobb-500) were randomly distributed in 5 dietary groups of 3 replicates with 15 chicks/pen as follow: (i) negative control group; (ii) positive control group; (iii) probiotic primalac®; (iv) prebiotic fermacto®; (v) antibiotic virginiamycin®. On day 14, all birds were inoculated by 10 times the standard dose of coccidiosis vaccines except the negative control group. On 18, 19 and 20 days of age, the challenged birds were also gavaged by C. perfringens type A. The results of this study indicated significant reduction population of C. perfringens in the intestine of chickens due to the influence of dietary supplementation of prebiotic. Among the infected treatments, the highest OPG was observed in positive control group and prebiotic treatment had the lowest. Antibiotic treatment significantly reduced the population of lactic acid bacteria.