Response of some oxidative stress and inflammatory indicators to an acute exercise session following adaption to 8 weeks running training

The purpose of this study was to assess effect of eight weeks running continuous training on some oxidative enzyme response and concentration of acute phase protein after acute exercise session. Twenty sedentary healthy males were selected (Mean±SD; age: 23/95±2/50 yrs، weight: 73/85±6/46 kg، height: 174±4/75 cm) and randomly divided into equal two groups: experimental and control. At beginning، before and after one acute exercise session، blood samples were taken for evaluating serum haptogolobin (HP)، creatine phosphokinase (CPK) and lactate dehydrogenase (LDH). Then the experimental group was trained endurance running for eight weeks، 3 times per week. Initially، training started with % 60- 65 intensity of maximum heart rate reserve and took 20 minute time and finished with %85 maximum heart rate reserve intensity and took 30 minute time in last session. After eight weeks، all subjects participated in second acute exercise session and blood samples were taken again. Data were analyzed using repeated measure ANOVA and independent t test. Significance was indicated by P values ≤0. 05. A significant difference was observed in levels of HP serum (P=0. 035) and LDH serum (P=0. 001) in the second acute session in experimental group. Also serum HP level was significantly decreased after one acute session following eight weeks continuous running (P=0. 031). When two groups compared، a significant difference was observed in serum LDH in second acute exercise (P=0. 012). It can be concluded that eight weeks of continuous running training in sedentary healthy males cause of adaptation and decrease of generation oxidative Stress and Inflammatory indicators following acute exercise.