Repair Ethanol Induced Amnesia with Iranian Basilus subtilisin Male Wistar Rats

Compelling evidence suggests that the administration ofethanol (ETOH) induces amnesia or impairs memory retrieval.Probiotics are food supplements and pharmaceutical substances prepared from living microorganisms that with enhancement of microbial equilibrium of intestinal microbiota, insert useful effects on the host (human/animal). The aim of this study was examination of BS (Basilus subtilis), the native Iranianprobiotic isolated from poultry farm product on the rat passive avoidance. In this study use as 96 male wistar rats with 200-250 grams weight range. Ethanol was used for induction of amnesia. Rats were administrated with 0.1 ml phosphate buffer (PBS) with and without 1×10 9 cfu/ml of probiotic bacteria. The step-through passive avoidance used in the present study to examine long-term memory in male Wistar rats. Results indicate that post-training sub cortical (SC) administration of ethanol (1 mg/kg) induces amnesia. This amnesia was reversed in probiotic receiving groups. Results of this study showed that the Basilus subtilis from poultry farm enhance the learning and memory in male Wistar rats which received ethanol in passive avoidance learning test. Our data demonstrate the positive effect of this probeotic on learning and memory.