Study of One pot reaction of Dimedone and Nitro Benzaldehyde in the Present or absence of Cyanogen Bromide

Reaction of 1,3-dimethyl pyrimidine-(1H,3H,5H)-2,4,6-trione (1,3-dimethyl barbituric acid) with cyanogen bromide and aromatic dialdehydes in the presence of N-methyl Morpholine leads to the selective and efficient formation of a novel class of bifunctionalized linkaged heterocyclic stable bis-spiro[furo[2,3 d]pyrimidine-6,5'- pyrimidine]2,2',4,4',6'(3H,3'H,5H)-pentaones which are dimeric forms of barbiturate (uracil and thiouracil derivatives) at the range of 0°C to ambient temperature. Structure elucidation was carried out by 1H NMR, 13C NMR and FT-IR spectroscopy. A proposed mechanism was discussed for the formation of products.