Relation between the prevalence of antibodies against cytomegalo, rubella, and herpes simplex viruses in women with spontaneous abortion compared to normal delivery

This study aimed to determine the prevalence of serum IgG and IgM antibodies against cytomegalovirus (CMV), rubella and herpes simplex virus (HSV) in the women with spontaneous abortion compared to women with normal delivery. This case-control study was performed on 81 women with spontaneous abortion (case) and 98 women with normal delivery (control) referred to the obstetrics and gynecology clinics of Tehran hospitals in 2013. All the serum samples were tested for CMV, HSV and rubella IgM and IgG antibodies using ELISA kits. The data along with demographics and the gestational age of the mothers were recorded in the questionnaire and analyzed using SPSS. The positive IgG antibodies against CMV were 87.7% (n=71) and 90.8% (n=89) in the case and control groups, respectively. Moreover, the positive IgM antibodies were 25.9% (n=21) and 12.2 %(n=12) in the case and control groups, respectively (P= 0.02). IgG antibodies against rubella in the case and control groups were 75.3% (n=61) and 86.7% (n=85), respectively. Also, IgM antibodies were 1.2% (n=1) and 2% (n=2), respectively (P=0.03). IgG antibody against herpes was 79% (n=64) and 85.7% (n=84) in the case and control groups, respectively; IgM was positive (3.1%) in only 3 cases. Results of the present study reveal that the IgM antibody against CMV in case group was significantly higher than the control group, which shows the role of CMV in the occurrence of abortion.