The Application of 99mTc-Chitosan Microparticles in Lung Imaging of Mice: A Short Report

In nuclear medicine, lung perfusion scintigraphy is performed by radiolabeled particles, 99 mTc-albumin macroaggregated. Synthesizing of the particles has some difficulties. In order to resolve this problem, chitosan microparticles were used as an alternative choice. The qualitative control tests including: the determining particles size, the labeling efficiency and stability in saline buffer and imaging studies in the mice were performed. The size of particles was 90-110 micron. The labeling efficiency was 94±3%, the good stability in saline buffer and high accumulation of activity in mice lung were seen. The results showed that the 99mTc-chitosan microparticles may be considered as a promising radiopharmaceutical of lung perfusion scintigraphy that needs more investigations.