Association study of calpain-10 gene polymorphism in patients with polycystic ovarian syndrome

Polycystic Ovarian syndrome (PCOSS) is a common endocrine disorder with prevalence of 5-10% globally among women of reproductive age. PCOSS is being characterized by chronic anovulation، polycystic ovaries، hyperandrogenism، hirsutism، overweight، insulin resistance and infertility. It is well-known that PCOSS is a complex trait alike to Type-2 Diabetes where both genetic and environmental factors play a crucial role in pathogenesis of the disease. A couple of Type-2 Diabetes susceptibility genes including those for insulin secretion and action such as Calpain-10 showed considerable contribution to genetic predisposition of PCOSS. Since Calpain-10 gene seems to be a strong candidate gene to PCOSS، we aimed to investigate the role of Caplain-10 gene polymorphism UCSNP-44 (T/C) located in a transcription enhancer element of the gene to the disease susceptibility. We carried out a cross-sectional case-control study. Using simple random sampling ninety healthy women were selected. All ninety patients fulfilled the 2003 Rotterdam criteria of PCOSS. The subjects were genotyped for Caplain-10 gene polymorphism UCSNP-44 (T/C) using PCR-RFLP. Differences in genotype distributions between case and control subjects were examined via a chi-square test. Although PCOSS showed high prevalence among women in Bandar Abbas city، Caplain-10 gene polymorphism UCSNP-44 (T/C) UCSNP44 doesn׳ t influence susceptibility to PCOSS.