Association Between Abdominal Obesity Indicators and Serum Levels of Homocysteine in Migraine Patients: A Cross-Sectional Study

The current studies showed that obesity could lead to hyperhomocysteinemia as well as migraine.. Thus, this study aimed to assess the association between abdominal obesity and serum levels of homocysteine in migraine patients..Patients and This cross-sectional study was conducted on 120 migraine patients, aged 15-67 years, who were referred to Isfahan Korshid and Imam Mosua Sader clinics in 2013. Abdominal obesity indicators such as waist circumference (WC), hip circumstance (HC), waist-hip ratio (WHR) and waist-height ratio (WHtR) as well as fasting homocysteine concentration were measured for all patients. Data was analyzed by the SPSS 19 software using t-test, χ2 and regression.. In this study, 7.7% of men and 18.8% of women had hyperhomocysteinemia. Abdominal obesity was prevalent in 3.8% of men and 27.1% of women. In the entire population, homocysteine concentration was positively associated with WC (P ≤ 0.001), WHR (P ≤ 0.001) and WHtR (P ≤ 0.001), either in crude or adjusted models. In addition, such relationship was seen in women. Amongst men, a significant association was found between WC and homocysteine levels (P = 0.03), yet the association between WHR (P = 0.06), WHtR (P = 0.08) and homocysteine concentration was marginally significant.. Waist circumference, WHR and WHtR were positively associated with homocysteine concentration in migraine patients. However, further studies particularly of prospective nature are required to confirm our findings..