The effects of STW 5 on lung tissue protection in CLP rat model

In this study, the protective effects of an herbal drug known as STW 5 (Iberogast®) -in dose dependent manner- on oxidative lung damages in rats induced by experimental sepsis was assessed. For this purpose, the rats were divided into six groups: Sham-operated (SOP); CLP; CLP + STW 5 (2.5, 5 &10 mg/kg) and CLP + Indomethacin (positive control). The drugs were injected i.p immediately after sepsis induction and the lung tissues were examined histophatologically 24 hour after CLP. Based on the qualitative and quantitative histological data, it was found that induction of sepsis was associated with extensive infiltration and sequestration of PMN and also high histologic index of the severity of lung injury. In compare to Indomethacin, the treatment of rats with STW5 did not improve these parameters. The data shows that STW 5 cannot modulate pathological parameters leading to lung damages in CLP rat model.