FROM GENOME TO GENE: A REVIEW OF GENES AND GENETIC VARIATIONS TO BE ASSOCIATED WITH METABOLIC SYNDROME
Author(s):
Abstract:
Background
The prevalence of non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries. Metabolic syndrome is a disorder of energy utilization and storage، diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity، elevated blood pressure، elevated fasting plasma glucose، high serum triglycerides، and low high-density cholesterol (HDL) levels. The present review aims to discover the genetic variant reported in association with MetS. Methods
The database for genotypes and phenotypes (dbGaP) and the database for genetic associations and human genome (HuGE navigator) were utilized in order to search for genes and their corresponding polymorphisms related to MetS. Additionally، an electronic literature search for other Iranian studies and the genetic aspect of TLGS was completed using PubMed. Results
For phenotype selection in PheGenI، 30 traits were chosen and after the analysis، 21 of them were in common results with MetS. After finding the common variation between traits and MetS، omitting the repeated SNPs، 173 variations were remained. Finally، results distinguished six of the most important genetic regions found to have strong association with MetS. Conclusion
Identifying major genes that are responsible for the metabolic syndrome may improve the medical care for treating individuals with metabolic syndrome، and eventually may lead to personalized medicine in which treatment is tailored genetically to the patient’s needs. The present candidate regions is a respectable start to replicate genetic studies in large affected Iranian individual which we hope leads us to improve our medical care in this field.Keywords:
Language:
Persian
Published:
Iranian Journal of Diabetes and Lipid Disorders, Volume:14 Issue: 4, 2015
Pages:
225 to 234
magiran.com/p1446176
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!