Association of Coronary Artery Disease and ABO Blood Groups

Cardiovascular diseases are the most cause of death in most part of the world and Iran. Studies had shown that ABO blood groups can be associated with coronary artery disease. Regarding to its importance and high prevalence of it in Guilan and existence of controversial results about blood groups and coronary artery disease we design this research. Evaluation the association of ABO groups in patients referred to Heshmat hospital. This is a case control study in which 274 records of patients referred to Heshmat hospital underwent coroniary areteries angiography were evaluated. Patients were divided to two groups of patients and control equally 137 persons. Tool of study was a checklist for collectiong data. After data gathering and organization of them, thet were entered in SPSS software ver 19 and analysis was done with descriptive and analytical statistics (T test، Chi square, ANOVA). The mean age of patients was 59. 26±10. 08 years old and 55. 1% of them were male 44. 9% were female. There was significant difference between coronary artery disease and age groups (P=0. 014), age (P=0. 003), history of cardiovascular disease in patients (P=0. 006), history of myocardial infarction (P=0. 014). The most blood group in patient group was A. Although frequency of A, B and AB blood groups were more in patients group than control, there was no significant difference between them (P=0. 78). Only O blood group in female was significantly more than male (P=0. 018). There was significant relation between O blood group and history of MI (P=0. 043). Results of this study is probably dependent on genetic and environmental characterestics in Guilan region. It can be concluded that in our population, in female, having O blood group can predispose persons to coronary artery disease; however more studies is needed.