Role of Progesterone Administration on Endometrial Angiogenesis and other Endometrial Quantative Changes in Hyperstimulated Mice at Implantation Period

The vascular parameters changes from the morphological aspects resulted in changes in the rate of the embryo implantation. This event depend on the ovarian hormones. In this study, the quantiative changes of the endometrium was assessed after ovarian stimulation followed by progesterone (p4) treatment. Adult female mice were used in this study. Animals were divided in three groups. pseudopregnancy were induced in the control group. Then in the experimental group1 (ovarian induction group)and experimental group 2(p4 treated after ovarian induction), ovarian stimulation was done. P4 treatment was done daily in the experimental group 2 after pseudopregnancy. Finally, blood and tissue samples were taken for assessment of the ovarian hormone levels and histogical studies, respectively. Then statistical analysis was done. The results indicated the significant increase in the progesterone level, vascular sections, internal area of vessels, and the diagonal of the glandular lumen in two experimental groups (1&2) compared to the control group (P ≤ 0.05). Also, P4 treatment after ovarian induction resulted in the significant increase in the P4 level and vascular section number in the experimental group 2 compared to the experimental group1 (P ≤ 0.05). P4 treatment after ovarian induction improve the morphological condition of the endomertium compared to the ovarian induction group. Therefore, it may result in an increased rate of successful implantation.