Effect of Intravitreal Bevacizumab Injection on Sustained Intraocular Pressure

To evaluate the effect of intravitreal Bevacizumab (IVB) injection on sustained intraocular pressure (IOP) This non-randomized prospective study was conducted on 359 eyes of 359 patients in Amir Almomenin (Rasht) and Labbafinejad (Tehran) Hospitals. After history taking and complete ocular examination, IOP was measured one week and one day before injection (twice at each session), and 1, 7 and 30 days after injection (three times at each session). All IOP measurements were obtained by a single examiner. Of all eyes, 306 eyes (159 right and 147 left eyes) of 306 patients (42.2% men, 57.8% women) were eligible for the study. Indications included diabetic retinopathy (277 eyes; 90.5 %), retinal vein occlusion (20 eyes; 6.5%), neovascular age related macular degeneration (9 eyes; 2.9%). No sustained increase in IOP was observed in the injected and non-injected fellow eyes. No significant association was found between the IOP elevation and subject gender or indications for injection. IVB injection in eyes without a history of glaucoma did not lead to a sustained increase in IOP during one month after injection.