Role of the prooxidant - antioxidant balance in CAD

Background and aim. The balance between ROS generation and antioxidant activity is critical to the pathogenesis of oxidative stress related disorders. In this study the prooxidant – antioxidant balace and its correlation with lipid profile and uric acid was determined, to evaluate the PAB as a prognostic factor for CAD. Materials and Methods Seventy – two patients and sixty eight healthy volunteers were enrolled in this study. The values of PAB was determined by using standard solutions and ELISA method. Triglyceride, total cholesterol, LDL- cholesterol, HDL – cholesterol and uric acid were measured by enzymatic method. Results The PAB values of CAD patients and control group were 70.01±3.36 (HK unit) and 66.40 ± 2.84 (HK unit) respectively. There was no significant difference between PAB values among two groups (P= 0.41). There was no significant difference between uric acid levels among two groups (P= 0.46). There was a significant correlation between the uric acid values among patients and healthy volunteers and PAB values (P <0.01). There was a significant correlation between the TG, chol LDL, HDL HDL values among patients and healthy volunteers and PAB values (P<0.05). Discussion and conclusion This study showed, oxidative stress could be used as a significant risk predictor in the coronary artery disease patients.