Study Of Hepato Protective Effects Of Avicenniamarina Hydro Ethanolic Leaves Extract In Male Rats Induced With Carbone Tetrachloride
Author(s):
Abstract:
Background and Aim
The inflammation and necrosis in hepatocyte causes disorders in liver functions when induced with toxins. Medicinal plants have hepatoprotectivity effects and can inhibit the heptotoxicity progressing in the liver. In this study the hepatoprotectivity effect of Avicenniamarina hydro ethanolic leaves extract (AME) were investigated in malerats induced with carbone tetrachloride.Methods
In this study, 42 male rats with 220-250 gr body weight were divided randomly in 6 groups (n=7): control, sham(taking olive oil, 2ml/kg/day, i.p),witness group(taking carbontetrachloride 1:1 with olive oil,2ml/kg, single dose, i.p) and treatedgroups: (1,2 and3inducedbycarbontetrachloride 1:1 with olive oil, 2ml/kg, andafter2 hours 200, 400 and 800mg/kg AME /dayfor4 days,i.p).Thecontrolgroup (taking normal saline, 0.5ml/day,i.p). Aftertheexaminationthebloodsampleswerecollectedfromheartdirectly and albumin, total protein, totalbilirobin and liver enzymes wereanalyzed.Results
Carbon tetrachloride reduced serum albumin and total protein and increased total bilirubin in groups induced with ccl4 significantly (P<0.001). In treated groups serum albumin and total protein increased and total bilirubin decreased compared with witness groups significantly (P <0.05). CCl4 increased ALT, AST and ALP significantly and in treated group reduced significantly(P<0.001).Conclusion
The Avicennia marina hydoethanolic extract has antioxidant and flavonoids compounds. These materials could be able to protect the tissues, such as liver tissue, from toxic agentssignificantly.Keywords:
Language:
Persian
Published:
Armaghane-danesh, Volume:20 Issue: 10, 2016
Pages:
858 to 872
magiran.com/p1498344
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!