Biosynthesis of Gold nanoparticles by Staphylococcus aureus 29213 and Evaluation of its antibacterial and cytotoxicity
Abstract:
Aim and
Background
Nowadays, using nanocarriers and targeted drug delivery have attracted more attention. Nanocarriers, especially gold nanoparticles have been presented as an appropriate choice for targeted drug delivery. Today, applying biological systems like microorganisms in synthesizing gold nanoparticles has been the focus of attention. Biosynthesis and aggregation of nanoparticles using clean biological systems which are biocompatible and non-toxic are known as green methods, especially compared with other chemical methods of synthesizing nanoparticles.Materials And Methods
In this study, Staphylococcus aureus was used for the biosynthesis of gold nanoparticles and the effects of their antimicrobial and cytotoxicity were examined.Results
Perfectly spherical gold nanoparticles with an average size of 25 nm were synthesized. Techniques using different concentrations of gold nanoparticles were studied by MTT assay, and the concentration of more than half of the cells survived. MIC and MBC gold nanoparticles microbial tests for vancomycin-resistant Enterococcus faecium utilized for all concentrations of nanoparticles were dead bacteria.Conclusion
Using Gold Nanoparticles omitted vancomycin resistance in vancomycin-resistant Enterococci.Keywords:
Nanoparticles , Biosynthesis , Cytotoxicity , MIC , MBC , MTT assay
Language:
Persian
Published:
New Cellular & Molecular Biotechnology Journal, Volume:6 Issue: 21, 2016
Pages:
67 to 73
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