Paget S Disease of Bone; A Case Report

Paget’s disease is a progressive skeletal disorder, which involves the gradual destruction of the bones. Regarding the low prevalence of this disease in Iran, this study aimed to present a case of Paget’s disease in an asymptomatic patient. CASE REPORT: A 44-year-old male patient with elevated alkaline phosphatase (ALP) level in yearly examinations was referred to an internal medicine clinic. Considering the normal results of other examinations, high ALP level was found to be of an osseous origin. However, no bone deformity was detected in the patient. Bone scan and simple radiography were indicative of Paget’s disease considering the high osteoblastic activity in the right hip and right sides of T1 and L3 segments. Diagnosis of Paget’s disease was confirmed by bone biopsy. The patient was initiated on oral alendronate (35 mg daily) for six months. Following this period, ALP level reduced, and the treatment is still in progress.

According to the results of this study, although Paget’s disease is a skeletal disorder, it could remain asymptomatic and occur without any deformities.