Meta-analysis of studies on the effect of vitamin D supplementation on blood glucose, lipid profile and inflammatory markers in patients with diabetes

Vitamin D deficiency and type 2 diabetes are both common diseases. Numerous studies have examined the relationship between the two. The purpose of this study was to investigate the effect of vitamin D supplementation on glycemic status, lipid profile and inflammatory markers in patients with diabetes. Type of systematic review and meta-analysis, which is actually a review on the studies available. Beginning a search extensively on electronic resources English, including EMBASE, Web of science, Medline Scopus and Who and electronic resources Persian including SID and Google scholar for diabetes-related research papers do. The test of heterogeneity, studies with significant heterogeneity in vitamin D, HOMA-IR and insulin sensitivity were the random effects model was used and the mean difference and 95% confidence intervals between the two groups in the vitamin D, 1.87 and (-5.49,9.23), HOMA-IR 0.09 and (-.023,0.05) and insulin sensitivity, 0.24 and (-0.75,0.26), respectively. The overall results of this study showed that the meta-analysis, vitamin D and insulin sensitivity in diabetic patients is effective and HOMA-IR is not effective on patients with diabetes.