Calcium‐Vitamin D Co‐supplementation Affects Metabolic Profiles, but not Pregnancy Outcomes, in Healthy Pregnant Women
Author(s):
Abstract:
Background
Pregnancy is associated with unfavorable metabolic profile, which might in turn result in adverse pregnancy outcomes. The current study was designed to evaluate the effects of calcium plus Vitamin D administration on metabolic status and pregnancy outcomes in healthy pregnant women.Methods
This randomized double‑blind placebo‑controlled clinical trial was performed among 42 pregnant women aged 1840 years who were at week 25 of gestation. Subjects were randomly allocated to consume either 500 mg calcium‑200 IU cholecalciferol supplements (n = 21) or placebo (n = 21) for 9 weeks. Blood samples were obtained at the onset of the study and after 9‑week trial to determine related markers. Post‑delivery, the newborns weight, length, and head circumference were measured during the first 24 h after birth.Results
Consumption of calcium‑Vitamin D co-supplements resulted in a significant reduction of serum high‑sensitivity C‑reactive protein levels compared with placebo (−1856.8 ± 2657.7 vs.707.1 ± 3139.4 μg/mL, P = 0.006). We also found a significant elevation of plasma total antioxidant capacity (89.3 ± 118.0 vs. −9.4 ± 164.9 mmol/L, P = 0.03), serum 25‑hydroxyvitamin D (2.5 ± 3.5 vs. −1.7 ± 1.7 ng/mL, P Conclusions
Although calcium‑Vitamin D co‑supplementation for 9 weeks in pregnant women resulted in improved metabolic profiles, it did not affect pregnancy outcomes.Language:
English
Published:
International Journal of Preventive Medicine, Volume:7 Issue: 3, Mar 2016
Page:
9
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