Effect of phenylbutazone on the duration of various parameters after anesthesia induced by thiopental sodium in male dogs

Taking drug interactions into consideration is an important aspect of therapy and being aware of such interactions may help to achieve an effective treatment. The purpose of this research was to investigate the possible interaction between phenylbutazone and sodium thiopental in male dogs. Twenty one mixed breed dogs were randomly divided into two control and experimental groups. Normal saline and sodium thiopental were intravenously administered to animals in the control group. Equivalent dose of sodium thiopental was administered following the injection of phenylbutazone via the same route. After anesthesia, time intervals needed for the return of pulpebral reflex, opening of eyes, tongue movement, extension of the limbs, head and neck movement, sitting position, trying to stand, imbalanced walking, and normal walking were recorded. Results show that, the average time periods in the experimental group were generally more than those in the control group. It was also shown that the duration of the above parameters were significantly higher in heavier dog (>18kg) compared to the lighter ones (