The Effects of Moderate-Intensity Interval Training on the Resistance to Induced Cardiac Ischemia in Adult Male Rats

Myocardial infarction is one the major causes of mortality in the world. The purpose of this study was to investigate the effects of moderate-intensity interval training on the level of resistance to induced cardiac ischemia in male adult rats.
In this study, 16 adult male Wistar rats were randomly divided into two groups of 8 mice: Control and moderate-intensity interval training (MIIT). At the end of 16th week of the training, all rats intraperitoneally received isoproterenol (dose, 85mg/kg) for 2 consecutive days, then cardiac function parameters [heart rate, diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular±dp/dt max], Biochemical indicators of tissue damage (heart tissue CTnI and TNF-α) were measured; also, the extent of heart tissue damage was evaluated by histopathological examination. The data were analyzed using nonparametric Mann-Whitney test and independent t-test. The significance level was considered as p≤0.05.
No significant differences were seen between the groups in any of the cardiac function parameters [HR (p The results showed that moderate-intensity interval training has protective effects against cardiac damage caused by injection of isoproterenol.