THE ROLE OF BOMBESIN IN PREABSORPTIVE SATIETY

Spontaneous cessation of eating and feeling of fullness before any digestion or absorption of food stuff begins,indicates that G.I. tract sensory nerves or hormone like secretion of upper G.I. tract can causes preabsorptive satiety. Some neurotransmitters or hormonal secretions are assumed to be responsible for this phenomenon, one of them is called bombesin, which mimics neurotransmission activity in mamalian's G.J. tract. Bombesin available in lateral ventricles activates paraventricular substrates and thus causes preabsorptive satiety and hypoinsulinemia. Intraperitoneal injection of bombesin reduces food intake and increases intervals between meals. Also bombesin and GRP(Gastrin Releasing Peptide) causes release of hormone which brings along feeling of fullness and as a result cessation of eating.