Protective Effects of Adenosine Receptor Agonist in a Cirrhotic Liver Resection Model

To investigate the role of CGS21680, a selective adenosine A2A receptor agonist, on a bile-duct-ligated cirrhotic liver resection model in rats..
Male Wistar rats were allotted into 3 groups (n = 7 per time-point): the control group, the bile duct ligation CGS21680 group (BDL CGS), and the bile duct ligation group (BDL). Biliary cirrhosis had been previously induced by ligature of the common bile duct in the BDL CGS and BDL groups. After 2 weeks, the animals underwent partial hepatectomy (50%). The BDL CGS group received a single dose of CGS21680 15 minutes prior to hepatectomy. Blood samples were collected and analyzed..
Aspartate transaminase levels were found to be lower in the control vs BDL groups (1, 3, and 24 h) (P Administration of CGS21680, an adenosine receptor agonist, after the resection of bile-duct-ligated cirrhotic livers led to improved liver function, regeneration, and microcirculation..