Protective Effects of Voluntary Exercise and extract of Salvia officinalis on diazinon induced Hepatotoxicity in Rats

Inroduction & Diazinon (DZN) is organophosphate pesticides which as environmental pollutants cause oxidative stress. This study was done to determinate protective effects of exercise program and Salvia officinalis extract on liver tissue damages from diazinon.
Material and in this study, 35 wistar rats randomly divided into equal groups including: control, DZN, DZN - extract, exercise- DZN, exercise- extract – DZN. Salvia officinalis extract with 100 mg/kg dosage for 4 weeks and DZN with 200 mg/kg dosage for once via intraperitoneally injection. Animals were sacrificed 24 hours after the last injection and blood samples were collected from the heart, sera were used to measure the concentrations of ALT and AST via RIA method. Then liver removed of body and sections were prepared for histopathological studies. Data analyzed by one-way ANOVA and Duncan.
Number of hepatocytes and sinusoids capillary significantly reduced in DZN group compared to control (p Salvia officinalis extract and exercise improves the body's antioxidant status and reduces of oxidative stress against diazinon.