The Synthesis Investigation of (3-(4-Nitro Phenyl) Isoxazol-5-Yl) Methanol in the Presence of Tio2 Nano Particles

Isoxazole and isoxazolines are very useful heterocycles in organic medicinal chemistry .
Isoxazoline rings have been used by organic chemists for synthetic manipulation to aceess complex molecular architectures. drugs such as Isocarboxazid , valdecoxib , oxacillin, leftunomide and micafiungin are the examples to substantiate the pharmaceutical acceptance of such heterocyclic systems. [1]
This research work describes the synthesis of new compound of isoxazole family. First 4-nitro benzaldehyde (1) was transformed to 4-nitro benzaldoxime (2) by using NH2OH in pyridine . The in situ generated nitriloxide from reaction between (2) and NaOCl, was reacted with propargylalcohol in the presence of TiO2 nano particles By the increasing of nano particles the yield of compounds was increased .
The structure of all the synthesised compounds was characterized and confirmed by FT-IR and NMR spectroscopy techniques.