Assessment of T helper 17-associated cytokines in third trimester of pregnancy
Author(s):
Abstract:
Background
Preeclampsia is a common pregnancy-specific disorder associated with significant maternal and fetal morbidity and mortality worldwide. It has been proposed that the imbalance between two CD4 T cell subtypes, regulatory T cells (Treg) and Thelper 17 cells (Th17), is involved in the pathophysiology of preeclampsia.Objectives
To determine the serum levels of IL-17, IL-21, IL-23 and TGF-β in patients with preeclampsia.Methods
Blood samples were collected from 30 preeclampsia patients,30 normotensive pregnant women and 30 healthy individuals with no history of malignancies or autoimmune disorders based on simple sampling. The serum levels of IL-17, IL-21, IL-23 and TGF-β were measured by the enzyme linked immunosorbent assay (ELISA).Results
The serum levels of IL-17 and TGF-β were significantlyhigher in preeclampsia patients compared to normal pregnant group and healthy individuals (p>0.0001) but interestingly, the opposite was the case for IL-23 (p=0.005). However, there were no significant differences in IL-21 between preeclampsia and normal pregnant group.Conclusions
Our results conclude that contrary to IL-21, serum levels of IL-17 and TGF-β significantly increased in preeclampsia compared to normal pregnant women, supporting an imbalance of cytokine profile in preeclamtic patients.Keywords:
Preeclampsia , TGF-β , IL-17 , IL-21 , IL-23
Language:
English
Published:
Iranian journal of immunology, Volume:14 Issue: 2, Spring 2017
Pages:
172 to 179
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