Effect of Pistacia Atlantica Hydro Alcoholic Extract with Bone Marrow- Derived Stem Cells on Induced Knee Osteoarthritis in Rat

Osteoarthritis is a progressive joint disease. Mastic fruit has antioxidant and anti-inflammatory properties. Bone marrow stem cells have the ability to differentiate into chondrocyte. The purpose of this study is to evaluate the effect of Pistacia atlantica hydro alcoholic extract with bone marrow- derived stem cells on induced knee osteoarthritis in rat.
Fifty male Wistar rats were divided into 5 groups of 10. Then, under anesthesia on days zero and 3, fifty μl collagenase type 2 was injected in the left knee. After 10 weeks, osteoarthritis was induced. The rats were divided into 5 groups: control, Pistacia atlantica hydro alcoholic extract therapy, treatment by stem cell and Pistacia atlantica hydro alcoholic extract, stem cell therapy alone, and treatment with hyalgan. After 12 weeks of treatment for osteoarthritis, radiographic and histopathologic surveys and also measurement of antioxidant properties as MDA-TAC were performed.
The results after 12 weeks revealed that the group with stem cell and pistacia atlantica extract had a significantly different and favourable results compared the other treatment groups (p It seems that Pistacia atlantica hydro alchoholic extract with bone marrow-derived stem cells are effective in knee cartilage repair.