Synthesis, characterization and comparative study of cytotoxic effect of copper(II) and zinc β-diketonate complexes

Two mononuclear complexes [ZnII(MAA)(phen)(Cl)] (A) and [CuII(TTA)2] (B) (TTA = 4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione), (MAA = methyl acetoacetate and phen = 1,10-phenanthroline) were synthesized and fully characterized by UV–Vis and FTIR spectroscopy. In this study, the MKN-45 cell line used for MTT assay. Two complexes exhibited lethal effects against MKN-45 cell lines compared to the untreated control. The IC50 is observed about 1 µg/mL for both complexes. Besides, the migration studies revealed that complex (B) is more active than complex (A) against the MKN-45 cancer cell lines. In morphology assay, it was also found that many of the cells showed cytoplasmic shrinkage and loss of normal nuclear architecture.