The association of miR-27a (rs895819) polymorphism with the risk of type 2 diabetes

Type 2 diabetes is an endocrine desease and one of the most common metabolic diseases in the world, and some environmental factors and genetic background are involved in the disease. Genetically, a large number of gene polymorphisms have been identified to be associated with this disease, but few studies have been conducted in polymorphisms miRNA and their correlation with type 2 diabetes. Among miRNAs, miR-27a involves in the predisposition to type 2 diabetes, and mutations can alter the miR-27a function and cause diabetes. The aim of the present study was to investigate the association of miR-27a (rs895819) with the risk of type 2 diabetes.
In the present case-control study, 100 type 2 diabetes patients and 100 healthy individuals were randomly selected. Polymorphism miR-27a (rs895819) was investigated using PCR-RFLP method. To determine the balance or imbalance in two groups and the relationship between polymorphisms and the incidence of type 2 diabetes, Chi-square test was applied.
Significant differences in the genotype distribution of miR-27a (rs895819) in patients with type 2 diabetes in comparison to the healthy subjects indicated a P value equal to 0.038 (odds ratio: 2.63, 95% CI: 1.07-6.05).
The results suggested that there is an association between miR-27a genetic variants and the incidence of type 2 diabetes. However, further studies are needed to evaluate the significance of genetic variants in different populations.