Generalized granuloma annulare in association with breast carcinoma

The association of granuloma annulare and some neoplasms is controversial. However, there is an increase in the number of case reports and relevant studies supporting the concept of granuloma annulare being associated with certain types of hematologic neoplasms and solid tumors. Herein, we describe a 54-year-old woman with a 20-month history of generalized annular lesions that did not respond to conventional treatment and was followed by breast cancer. Only two cases of granuloma annulare and breast cancer have been reported so far in the literature. We believe that these cases emphasize on considering granuloma annulare as a possible paraneoplastic dermatoses.