Comparison of Proton Pump Inhibitors (PPI) with Anti-Helicobacter Pylori therapy in the relief of clinical symptoms of dyspepsia in a military hospital

Dyspepsia is related to Helicobacter pylori and is among the most common reasons of military patients’ referring to Gastroenterology clinics. This study was performed to compare the efficacy of anti-Helicobacter pylori (anti-HP) and Proton Pump Inhibitors (PPI) treatment in patients with dyspepsia.
This randomized clinical trial was performed on 160 patients with dyspepsia who were randomly received two treatment regimens including only PPI medicines and both PPI and anti-HP agents
After the treatment, almost all symptoms had significantly less severity in the patients receiving anti-HP treatment compared with those receiving only PPI treatment (p According to the results, it is recommended that anti-HP treatment be used to improve the symptoms severity in patients with dyspepsia.