Histological and Biochemical Analyses of the Effects of Royal Jelly and Vitamin C against Phenylhydrazine-Induced Cardiotoxicity in Mice

Phenylhydrazine (PHZ) as a strong oxidant agent causes variety of toxic effects including alterations in the biochemical and cardiac tissue. The aim of the present study was to investigate the effects of royal jelly (RJ) and vitamin C (vit C) against PHZ-induced cardiotoxicity in mice.
Adult male mice were randomly assigned to eight groups of eight mice each. PHZ was administered to four groups of mice at a dose of 60 mg/kg per 48 hours intraperitoneally for 35 days. Three of these groups received vit C (250 mg/kg per day) intraperitoneally, RJ (100 mg/kg per day) orally and vit C with same doses four hours before PHZ administration, respectively. A vehicle-treated control group and vit C, RJ and vit C control groups were also included.
RJ and vit C significantly decreased (p It seems that Vit C and RJ can minimize PHZ-induced cardiotoxicity in mouse through oxidative reactions inhibition.