The Comparision of Therapeutic Effect of Propolis Extract and Phenytoin on the Wound of Koi Fish Cyprinus carpio haematopterus

This study aimed to assess the healing effect of ethanolic extract of Propolis as a natural resinous substance, possessing various biological properties, on the surgically experimental ulcer of Koi fish. Thirty-six Koi fish were randomly divided into 4 equal experimental groups for initial adaptation. Then three limited surgically cut wounded fish from the every group were cured under desired experimental cares, as three treatment groups (two doses of 10 and 20 mg/gr of the Propolis Ethanolic Extract (EEP) and Phenitoean Sodium %1) and one control (only Vaseline). The experimental doses of EEP and Phenitoean were respectively used as the Vaseline base made and the standard commercial Phenitoean Soudium ointments, one time a day for 10 days, as well Vaseline treatment (for the control group). The data were analyzed, using descriptive statistics methods. The results showed that dose of 2% of EEP were the most effective in the treatment of experimental surgically wounds. The signs of the wound were more healed in the 2% group, however the external and internal health effects were observed for the other dose of EEP (%1) and the standard Phenitoean (with criterion of cured skins quality signs, internal haemoragies, observed edema, inflammation and tissue adhesions) after 10 days. The control group wounds had retained the most signs of infection and skin damages, as well the internal viscose.