Serum Lipid Profile Alterations in Acute Leukemia Before and After Chemotherapy

Abnormal serum lipids profiles have been reported in human malignancies. Attempts have been made to correlate serum lipids in leukemia patients with the disease activity and response to chemotherapy.
Material and The aim of this study was to evaluate a possible prognostic significance of serum lipid profile in patients with acute leukemia before and after chemotherapy.
Fasting blood samples were obtained from 78 previously untreated patients at Tehran University of Medical Sciences hospitals at the time of diagnosis and after chemotherapy with complete remission. Total cholesterol, serum triglyceride, HDL-C and LDL-C were estimated by enzymatic kits.
A total of Seventy eight proved cases of ALL and AML with mean age of 24.87 years were studied out of which 53.8% were males and 46.2% were females. An altered serum lipid profile was observed at the time of diagnosis of patients. Statistically significant values included elevated TG(194.41±18.28mg%), reduced TC (128.97±8.53mg%),LDLC (82.84±6.76mg%) and HDLC(25.30± 1.22 mg %).After complete remission the lipid profile significantly was different, a reduction in TG (127.84±8.59mg%) and elevated TC(168.01±11.66mg%),LDLC(105.10±6.41mg%),and HDLC (37.38±1.78mg%) were observed.Values are given as mean±SD.
These results support the idea that cholesterol and its fractions(LDLC, HDLC), and TG determination might be considered as useful biochemical and prognostic markers in hematologic neoplasms.