Effect of four weeks of endurance exercise training on TNF-α and IL-10 genes expression following experimental MI in male rats

Background & Although the inflammatory process activation is necessary in the first period after myocardial infarction (MI), but it's over continuing can facilitate the recurrence of MI. Due to the positive effects of aerobic exercise training programs on inflammation, it seems that endurance exercise training (EET) have a positive effect on inflammatory condition in patients with MI. Accordingly, the aim of the present study was to investigate the effect of endurance exercise training on TNF-α and IL-10 genes expression following experimental MI in male rats.
18 rats were randomly divided to 3 groups: Sham, control and EET. MI was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days. EET intervention was initiated 2 days after MI and continued for 4 weeks. After extracting RNA from cardiac tissue and synthesizing cDNA, expression levels of TNF-α and IL-10 genes were relatively quantified using Real time-PCR. Data were analyzed by using one-way analyses of variance (ANOVA) at P
The TNF-α gene expression in the EET group were significantly lower than the control (P=0.002) and sham (P=0.001) groups. The IL-10 gene expression in the EET group was significantly lower than the control group (P=0.023), and the expression of this gene in the control group was significantly higher than the sham group (P=0.011).
It seems that EET may accelerate the process of improving the inflammatory status, through modulating the expression of TNF-α and IL-10 genes, after MI.