Novel Antibody informatics knowledge in therapeutic-drug discovery and diagnosis

By rising of Monoclonal antibodies (mAbs), it has been revolutionized medical sciences in fields of diagnostic kits and therapeutics drugs. One of well developed and increasing progressive field in immunoinformatic science is antibody bioinformatics. This field includes: designing of antibodies, modeling by different methods, refinement and affinity maturation, docking, humanization and reducing immunogenicity, stability, troubleshooting of structural degeredent and application of databases in industrial scale for drug-therapeutics and diagnostic usages. Antibody bioinformatics is one of complex and hardwork topics in highly profeesional designing which in near future will chage drug industry and diagnostics. Even now these drugs are introduced with this technique and using with high efficacy. Current review article explains on different aspects of bioinformatics and for first time tries to introduce Iranian researchers, engaged in different disciplines in basic biology sciences and pharmacology and its challenges.