Correlation between Vitamin D3 level and extrahepatic manifestation in chronic hepatitis type C virus patients
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Chronic hepatitis type?C virus (HCV) infection is one of the most common worldwide viral disorders, which leads to various clinical complications as well as extrahepatic manifestations. Furthermore, Vitamin D3 has also been reported to have relationship with the mentioned complications. Te aim is to evaluate the correlation between Vitamin D3 level and extrahepatic manifestation in chronic HCV patients.Materials And Methods
Tis cross?sectional study has been carried out on 90 patients with chronic hepatitis C. Te level of Vitamin D3 was assessed in plasma of 90 patients with chronic HCV. Genotyping was done and clinical and sign and symptoms of recruited patients were gathered. Extrahepatic anifestations were evaluated and the correlation of blood, hepatic, and immunological factors and the level of Vitamin D3 were assessed.Results
Most of our patients were male (92% vs. 8%). Twenty?nine percent had the insufcient amount of Vitamin D3 (2130 ng/ml), and the remains had the Vitamin D3 level between 1320 ng/ml. Furthermore, our assessment demonstrated that defciency of Vitamin D3 was associated with the extrahepatic manifestations such as purpura (odds radio [OR] [95% confdence interval (CI) 95%] = 8.80 [1.7444.47], P = 0.004), vasculitis (OR [95% CI] = 11.70 [3.0145.41], P Conclusions
According to our results, the extrahepatic manifestation in the patients with sufcient levels of Vitamin D3 would be less possible. In fact, it could be stated that defciency in the Vitamin D3 can have a signifcant relationship with these manifestations.Language:
English
Published:
Journal of Research in Medical Sciences, Volume:23 Issue: 3, Mar 2018
Page:
2
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