The Effect of Hydroalcoholic Extract of Cuminum cyminum L. on Anxiety in Gonadectomized Male Rats
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Objectives
Anxiety is one of the common psychological disorders among human populations, and is a disturbing feeling that associates an unknown and ambiguous danger. The aim of this study was to investigate the effect of hydroalcoholic extract of Cuminum cyminum L. on anxiety in gonadectomized male Wistar rats.Methods
In this experimental study, 32 male Wistar rats (weight, 230 ±20g), were divided into DMSO treated healthy group, DMSO treated gonadectomized group, or the extracts solvent (0.5ml), and gonadectomized groups (received 50 and 100mg/kg hydroalcoholic extract of Cuminum cyminum L.) (n=8). First, the hydroalcoholic extract was extracted by soxhlet, then, the extract powder was prepared using an oven. Testicles were removed by surgery. All injections were intraperitoneal, and half an hour after the injection, anxiety test was carried out using elevated plus maze. Anxiety evaluations standard indicators (staying period and the number of entering to free arm), were assessed and recorded for 5 minutes. Data were analyzed using one-way analysis of variance and Tukeys tests (pResults
The gonadectomized rats that received DMSO showed a significant reduction in the presence period and the number of entries to the open arm, as compared to the healthy group receiving DMSO (pConclusion
According to the results of this study, gonadectomy increases anxiety. Moreover, hydroalcoholic extract of Cuminum cyminum L. reduces anxiety.Keywords:
Anxiety , Cuminum , Rats , Castration
Language:
Persian
Published:
Qom University of Medical Sciences Journal, Volume:12 Issue: 1, 2018
Pages:
35 to 43
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