Atypical Klebsiella Species in a Third Level Hospital as Cause of Neonatal Infection
Author(s):
Article Type:
Brief Report (دارای رتبه معتبر)
Abstract:
Background
The opportunistic pathogen Klebsiella pneumoniae is one of the main causes of pediatric bacterial blood stream infections (BSI), which is complicated with sepsis and high mortality.Objectives
To identify atypical Klebsiella species affecting a sample of infected neonates with low antimicrobial response.Methods
Multidrug resistant blood cultures for Klebsiella from a Neonatal Service, were submitted to molecular identification by sequencing analysis of 16S ribosomal RNA.Results
The mean age of the newborns was 14.7 ± 5.6 days. A total of 6 out of 8 cases were sepsis, 1 case of pneumonia, and 1 a catheter-related infection. The molecular identification showed 3 cases of K. pneumoniae subsp. ozaenae, 2 of K. pneumoniae and K. variicola, and 1 case of K. oxytoca. The highest antimicrobial resistance was against cephalosporins and Trimethoprim/sulfamethoxazole.Conclusions
Klebsiella pneumoniae subsp. ozaenae was responsible for multidrug resistant strains of Klebsiella even in 37.5% of cases. In our clinical setting, the use of Amikacin and carbapenems are still useful to treat neonatal infections by Klebsiella even against K. variicola, which is the most resistant.Keywords:
Language:
English
Published:
Jundishapur Journal of Microbiology, Volume:11 Issue: 3, Mar 2018
Page:
10
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