Synergic Effect of Cu(II) Nanocomplex for the Fabrication of Highly Sensitive Voltammetric Sensor for Levodopa Determination

A novel modified graphite screen printed electrode (SPE) is prepared as an electrochemical sensor for determination of levodopa. The experimental results suggest that a screen printed electrode (SPE) modified with Cu(II) nanocomplex, [CuCl2(salophen)].H2O (salophen= o-phenylenediaminebis(salicylidenaminato)), accelerates the electron transfer reactions of levodopa. The fabricated sensor revealed some advantages such as convenient preparation, good stability and high sensitivity. The DPV data in 0.1 M phosphate buffer solution (PBS) (pH 7.0) allowed a method to be developed for the determination of levodopa concentrations in the ranges 5.0–900.0 μM, with the detection limits of 0.9 μM. The proposed method was successfully applied to determinations of levodopa in urine samples.