Title Evaluation of the relationship between serum Uric Acid level and outcome of patients with acute exacerbation of chronic obstructive pulmonary disease

Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in the production of uric acid (UA). Elevation of serum uric acid levels has been observed in hypoxic subjects, including patients with chronic obstructive pulmonary disease. Patients with chronic obstructive pulmonary disease (COPD) have been reported to have high serum levels of uric acid compared with control subjects. In this study, we examined the relationship between spirometric measures and serum uric acid levels in different staging of COPD and outcome patients
A total of 79 patients with chronic obstructive pulmonary disease with age range of 38-83 years were enrolled. 51 of the patients (64.6%) were men and 28 patients (35.4%) were female.Subjects aged 38 years or older (n = 79), who admitted in Imam Khomeini Hospital in Urmia with chronic obstructive pulmonary exacerbation without comorbid conditions. The uric acid level was measured from the morning blood sample of the patients and during the hospitalization, the patients were evaluated for serum uric acid levels and evaluated outcomes including recovery and discharge, ventilator connection, transfer to ICU and death. The correlation between serum uric acid and changes in FEV1 was also investigated.
The results of data analysis showed that the mean age of patients in the study was 62.94 ±15.06 years, and the mean uric acid and FEV1 in patients were 5.16± 2.50 mg / dl and 0.74 ±0.19 respectively. Significant differences between the level of serum uric acid in patients who have recovered and have been discharged (patients without adverse events) and patients with at least one of the cases (need to Vetilator, need for ICU or death) were not observed. There was no statistically significant relationship between severity of disease (FEV1 level) and serum uric acid level.
Serum uric acid levels have no predictive value for predicting the outcome of hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease. Also, the serum level of uric acid is not a reliable marker for determining the severity of chronic obstructive pulmonary disease.