Investigating the effects of co-treatment of type one interferons and granulocyte colony-stimulating factor on Glucose, triglycerides and cholesterol of blood serum in Syrian mouse
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background and
Purpose
granulocyte colony-stimulating factor (G-CSF) has a major role in blood cells differentiation especially in neutrophils, therefore G-CSF widely has been used in treatment of chemotherapy-induced neutropenia. Different lines of evidence indicated that G-CSF is increased in inflammatory situation and has inflammatory characteristics. Unlike G-CSF, type I interferones (IFNs) have been shown to have anti-inflammatory effects. The aim of this study was to investigate whether type I IFNs can normalize the effects of G-CSF on blood factors.Materials And Methods
forty-two mice (male, eight weeks) were divided into six groups of seven, which includes Group 1 (control) injection of distilled water, Group 2 injection 200 µg/kg b.w. G-CSF, Group 3 injection 200 µg/kg b.w. Alfa interferon (IFN-α), Group 4 injection 200 µg/kg b.w. interferon beta (IFN-β), Group 5 injection 200 µg/kg b.w. G-CSF� µg/kg b.w. IFN-α, Group 6 injection 200 µg/kg b.w. G-CSF� µg/kg b.w. IFN-β. After 28 days, blood was taken from each mouse heart and blood biochemical parameters (Glucose, Triglyceride, Cholestrol) was investigated.Results
surprisingly, in most cases, the G-CSF and type one IFNs alone or simultaneously reduced the levels of Glucose, triglycerides and cholesterol. Also the reduction of glucose, triglycerides and cholesterol were higher in G-CSF and INFs in compare with G-CSF alone. Our data raise the possibility that, G-CSF and INF-α/β have some similarity in signaling pathway which has to be investigated.Keywords:
: inflammation , IFN , ? , IFN , ? , G , CSF , blood biochemical parameters
Language:
Persian
Published:
Journal of Sabzevar University of Medical Sciences, Volume:25 Issue: 1, 2018
Pages:
93 to 100
https://magiran.com/p1836202
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