Effect of Curcumin on Histomorphometry of Endometrium in Polycystic Ovarian Syndrome in Mice

Polycystic ovary syndrome (PCOS) is a syndrome with complex endocrine and metabolic disorders and also associated with endometrial changes. According to antioxidant and anti-inflammatory effects of curcumin, the aim of this study was to evaluate the effect of curcumin on histomorphometry of endometrium in polycystic ovarian syndrome mice model.
In this experimental study 28 mice were divided into 4 equal groups. Control, PCOS control and experimental PCOS treated with curcumin (100 and 200 mg/kg, ip). PCOS was induced by a single intramuscular injection of estradiol valerate into PCOS control group and experimental PCOS group. Curcumin was intraperitoneally injected into experimental PCOS groups for 16 days. Saline solution was injected to the animals of control and PCOS control groups. At the end of treatment, the endometrial biopsies were stained with Hematoxylin-Eosin and pathological changes were examined. Data was analyzed using one-way ANOVA and Post Hoc Tukey statistical tests (P Compare to the control group, number of glands and thickness of endometrial significant decrease and thickness of epithelial cells and thickness of the endometrial glands epithelial cells significantly increase in PCOS control group (p Dose dependent administration of curcumin improves the endometrial histological damages of PCOS mice model.