The phytochemical and anesthesia effects of Myrtus communis essential oil co-administration with thiopental in male rat

Myrtus communis has certain effects including anti-anxiety, analgesic, anti-inflammatory and hypnotic. The aim of this study was to investigate the phythochemical and anesthesia effects of M. communis essential oil co-administration with thiopental in male rat were investigated.
In this experimental study, 24 male rats were randomly divided to three groups of 8 each, consisting of M. communis (MC) (500 mg/kg), thiopental (T) (40 mg/kg), and M. communis thiopental (MCT) (500 and 40 mg/kg, respectively). Duration of induction and Surgical Anesthesia (SA), walking time, heart rate, respiratory rate, temperature and depth of anesthesia (by withdrawal reflexes) were measured from 0 to 55 minutes.
MC could not induce SA. T induced anesthesia had group insignificantly faster than MCT (P>0.05). Duration of anesthesia in T group was shorter and recovery was faster compared to MCT group (P0.05). The respiratory rate and temperature (between 30 to 55 mints) in MCT group had a significant decrease compared with the other groups (P MC essential oil potentiates duration of T-induced anesthesia. With respect to pharmacological effects, MC could be used as a preanesthetic agent with T. Besides. More studies are needed to determine their efficacy to induce anesthesia in human.