Effects 12 weeks of endurance training on serum levels of angiopoietin-like protein 4 and lipids profile obese women aged 50-65 years

Angiopoietin-like protein 4 (ANGPTL4) is one of novel regulators of lipid metabolism which has role in obesity related diseases such as cardiovascular diseases. Therefore the purpose of this study was to the effect of 12 weeks of endurance training on serum levels of Angiopoietin-like protein 4 (ANGPTL4) and lipids profile in obese women aged 50-65 years.

Eighteen sedentary postmenopausal obese women (BMI>30Kg/m2) randomly assigned into experimental (n=10) and control (n=8) groups. Subjects in experimental group participated in 12 weeks of endurance training (running on treadmill at intensity of 60-80% of maximal hear rate). Serum levels of ANGPTL4, lipids profile and body composition indices measured before and 24 hours after last training session. Statistical analysis was done by paired and independent t-test and Pearson correlation coefficient and p

Paired t-test showed levels of ANGPTL4 (p=0.04), triglyceride (p=0.03), total colestrol (p=0.01) and very-low-density lipoprotein (p=0.01) significantly declined after 12 weeks of endurance training; however, with Independent t test no significant changes observed for none of blood factors between experimental and control groups (p>0.05). According to Pearson correlation coefficient there were no correlations between primary levels and changes of ANGPTL4 levels and those of blood factors assessed (p>0.05). However, significant correlation observed between ANGPTL4 changes and changes in waist circumference following 12 weeks of endurance training (p=0.05).

Endurance training has role in regulating serum levels of ANGPTL4 in sedentary postmenopausal obese women and through improving lipids profile decreases risk of cardiovascular disease