The Smart Specialisation and the roles of universities in the ecosystem of innovation in the evolution towards sustainability.

Globalisation and the rise of the knowledge economy have contributed to redefining and extending the roles of universities in society. Together with teaching (first mission) and researching (second mission), the third-mission concept and fourth mission was suggested to identify interactions between universities and the rest of society, and co-creation for sustainability. This transition have been transformed from entrepreneurial to transformative university. The basic enabler of innovation (co- creation and exploitation of knowledge, seeking for opportunity and capacity building), the basic principle of triple and fourth(quadruple)helix , and the role of universities in the third and fourth missions to develop capacities and support the change in concept of innovation through the Smart Specialisation Strategy(S3) and several studies in this context was discussed. from the perspective of innovation policy, several trend and problem in lagged and developing countries in conclusion was discussed.