Axon Guidance Proteins: A Novel Target Point for Temporal Lobe Epilepsy

Epilepsy is primarily a neuronal network disorder characterized by recurrent and unpredictable seizures. Epilepsy is not only characterized by marked changes in ion channels but also by the abnormal synaptic protein expression. It has been reported that the expression of axon guidance proteins was changed in experimental models of epilepsy. In this letter to the editor, we review and discuss the changes of axon guidance proteins in epilepsy. Collectively, further insight into dysregulation of axon guidance proteins may help to develop novel therapeutic strategies for epilepsy.