Antibacterial and Ciprofloxacin-Potentiation Activities of Cinnamomum zeylanicum Extracts against Some Pathogenic Bacteria
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background and Objectives
Efflux-based systems may play a role in resistance to fluoroquinolones in Gram-negative pathogenic bacteria. Extracts of some medicinal plants contain molecules that can act as efflux pumps inhibitors. In this study, we aimed to evaluate antibacterial activities of ethanolic and chloroform extracts of Cinnamomum zeylanicum and their possible synergistic activity with ciprofloxacin against some Gram-negative pathogenic bacteria. We also analyzed the extracts for presence of efflux pump inhibitors against the examined bacteria.
Methods
Powdered dried leaves and branches of C. zeylanicum were extracted with ethanol (85%) and chloroform by the maceration method. Minimum inhibitory concentrations of the extracts alone or combined with ciprofloxacin and phenylalanine-arginine β-naphthylamide (an efflux pump inhibitor) were determined against Pseudomonas aeruginosa, Acinetobacter bummani, Escherichia coli and Salmonella enteritidis using the double serial microdilution method.
Results
The extracts of C. zeylanicum inhibited the growth of all studied bacteria. Synergistic effects were noted between the extracts and ciprofloxacin against all tested bacteria other than P. aeruginosa. Ciprofloxacin efflux pumps in E. coli, S. enteritiditis and A. baumannii were inhibited by the extracts of C. zeylanicum.
Conclusion
The extracts of C. zeylanicum could be used as ciprofloxacin-potentiating agents against some Gram-negative pathogens. Keywords:
Language:
English
Published:
Medical Laboratory Journal, Volume:13 Issue: 3, May-Jun 2019
Pages:
6 to 10
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